Superantigens free essay sample

Superantigens BY Juell 1 A superantigen is defined as a type of antigen which has the ability to cause polyclonal T cell activation via a large, nonspecific activation of T cells. There are three general families of superantigens: endogenous superantigens, exogenous superantigens, and B cell superantigens. Endogenous superantigens are encoded into the genome by different viruses; exogenous superantigens simply refer to toxins secreted by bacteria; and a-cell superantigens describe the superantigens which ctivate a-cells. Superantigens have the unique ability to bind to both T cells, as well as MHC class II molecules (MHC=maJor histocompatibility complex). Ultimately, the goal is to bring these two types of molecules together so that they can effectively activate even more T cells (up to 20% of all T cells) in a non-specific manner due to the superantigen binding to the Variable B region of T cells. Cytokines, which are immune system proteins which are secreted for the purpose of carrying signals mongst cells, are released as a result of this increased activation of T cells and may even induce toxic shock. We will write a custom essay sample on Superantigens or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page This Toxic Shock Syndrome is due to Staphlyococcus aureus, characterized by erythematous eruption and high fever. An important cytokine molecule, TNF-alpha (tumor necrosis factor alpha), is secreted amongst these cytokines and plays a vital role in the inflammatory response of the body. An over secretion of TNF-alpha may result endothelial and vascular smooth muscle changes, hich manifests as hypotension, shock, and features of sepsis. An example of a bacterium that elicits a superantigen response in humans is the bacterium Streptococcus pyogenes. The main difference between normal antigen responses and the superantigen response can be seen with different levels of T cell activation. While sapproximately . 001-. 0001% of T cells are activated with a normal antigen response, about 20% of T cells are activated with superantigens.

Upmarket Fiction The Forgotten Middle Child of the Publishing World

Upmarket Fiction The Forgotten Middle Child of the Publishing World Upmarket Fiction: The Forgotten Middle Child of the Publishing World Calling something â€Å"commercial† can sound like an insult in some circles, as if it’s a trifling entertainment not worthy of the term â€Å"literature.† In other circles, the term â€Å"literary† results in a half-stifled yawn, and is considered pretentious. A question you might ask when you’re writing is, "Can a book be both literary and commercial?† The answer is yes: you've just described "upmarket fiction." Can a book be both literary and commercial? Yes: that's upmarket fiction. While this article won't settle any age-old commercial vs. literary debates, it will help you get a better grasp on how to distinguish both types of fiction - and, above all, it answer the question you’ve been wondering: what is upmarket fiction?A brief history of the novel - and how terms like â€Å"genre† and â€Å"literary† came to beIn the 17th and 18th centuries, the novel was considered a genre in itself. It was a relatively new form of narrative, a drawn-out prose detailing fictitious matters. As Joshua Rothman notes in The New Yorker: â€Å"When Catherine Morland, the heroine of Austen’s ‘Northanger Abbey,’ is rebuked for reading too many Gothic novels, the proposed alternative isn’t ‘literary fiction’ but non-fiction (a friend suggests she try history). ‘Northanger Abbey’ was written in 1799.† How did distinctions like commercial, literary, and upmarket come to be? Find out inside. 50 Book Marketing Ideas Every Author Needs to Know Read post Just like with choosing your degree, understanding the market from the outset of the process is crucial. If you’re hoping to make a career off of your novels, you need to study your market, your competitors, and to identify where your story will fit there. Why is it so important to be able to classify what kind of fiction you're writing? Find out here Even if your book is classified as commercial, that does not mean it has less merit as a piece of literature. Commercial and literary fiction both have their place: just like a spoon works better for ice cream and spaghetti requires a fork. This fiction is kind of like a spork, then: it can be used for either occasion.The classification is a sales tool - it’s important to know. In the end, if you can write a book that someone enjoys reading, that someone derives meaning from, that challenges someone to think, that helps someone unwind, that’s fun, or sad, or uplifting - in other words, if you can write a book that speaks to someone, then, well done. Not sure if your book is commercial, literary, or upmarket fiction? Take this quiz to find out http://bzfd.it/2xQofFP Are you still not 100% sure how to classify your novel? Take our quiz to find out!What are some of your favorite works of commercial, literary, or upmarket fiction? Share them with us in the comments below!

This is a COMPANY LAW AND CAPITALISM (LLB) problem question; the Essay

This is a COMPANY LAW AND CAPITALISM (LLB) problem question; the question is on the assignment criteria field of this application form below - Essay Example and Boris are the executive Directors of the Company, but from the perspective of ownership of shares, it may be noted that Clarke Bros has a greater ownership stake, since they own 5% of the shares while Boris and Amber own 2% each. Berle and Means point out that with the growing size of corporations, ownership and management have been separated1 however companies are now so dominated by directors that their shareholders may be denied an effective say in the decisions of the Company. Justice Plowman in the case of Parke v Daily News Ltd2 held that the primary duty of the directors of a corporation is to their shareholders, superseding their duty to their employees. In the execution of his duties, it is inevitable that a Director will face a conflict of interests, but he is required to be self regulated by a strong code of ethics in his dealings. The Executive Director is the principal agent of the Company but under the law, has been held to be subject to the same standards of loyalty and good faith in his duties as that expected from trustees3 and therefore has a fiduciary duty to the shareholders4. However, the functions of directors originated as a flexible concept in the courts in the nineteenth and twentieth centuries. For example in the case of directors in Turquand v Marshall, the Court held that it â€Å"could not interfere with the discretion exercised by them†.5 In the case of Re Dunham and Co, the Court found that the director has been guilty of â€Å"considerable negligence† yet held that he had not breached his duty of diligence and care.6 However the duty of skill of a Director was best laid out by Romer J in the Re City Equitable Fire Insurance Co Ltd7 where he stated that while a Director was expected to exercise a certain level of skill and diligence that an ordinary reasonable man would apply under the circumstances, this did not mean that he was required to demonstrate a level of skill that was not commensurate with his experience. Moreover, a

Car Advertising Assignment Example | Topics and Well Written Essays - 1750 words

Car Advertising - Assignment Example Considering the car market in UK, till 1980, the general opinion of Audi was that it was a car built in Europe and customers were not certain of even the nation of building, the technical capacities and the car had no specific image. The car was not clearly positioned according to the Louis Harris Car Image Study. The position of the car changed to some extent and by 1987, the car slowly moved towards the group of prestige cars. This was due to the "Vorsprung durch Technik" Campaign of the 1980s. Though the car was of the same size as Ford and Vauxhall, it was positioned as a car above them in terms of image. Further improvement was achieved in 1995 when Audi took advantage of the marketing opportunities that were available to it and to an extent this was due to the new models that were introduced. These were called Audi A8 and the Audi A4 and both these cars were far better that the previous models that this brand had. (Members only - how advertising helped Audi join the prestige ca r club) The models were liked by the press and the potential customers, and the particular brands have won a number of awards. This range of models was an improvement on the previous models that it had and those were called Audi 80 and Audi 100. Yet the brand had strong opponents in terms of brand names and prices. There were also new launches coming up from the competitors and the brand had not many advantages in terms of product itself. Thus, it was essential to establish the brand on certain parameters. The advantage of the brand getting into the prestige segment was that it would permit the brand to retain value after a few years of usage and this would encourage the users to buy the car. This can be seen in the case of Mercedes C class, Saab 900i, and Ford Mondeo 2.0 Si, where Mercedes retained 87.5 percent of the value, Saab retained 76 percent and Ford retained only 61 percent. Naturally, the car with the highest prestige would provide unseen advantages for its buyer and thus would f ind it easier to sell. (Members only - how advertising helped Audi join the prestige car club) The general positioning in Britain seems to be with Porsche and Ferrari as members of the Super Prestige group, BMW, Mercedes and Jaguar being members of the prestige group; Volvo and Saab being members of the quality cars group; Ford, Vauxhall, Rover and Renault being members of the mainstream cars group and Kia and Proton being members of the budget cars group. The cars in the prestige and super prestige group are able to charge a higher price, while the sales are the highest for the mainstream cars. In terms of positioning, it was always the objective of Audi to be a member of the prestige cars group. (Members only - how advertising helped Audi join the prestige car club) The logic for this is based on volume of production, desired profits and other matters. The consumers also view cars within different groups in a manner that keeps their image in line. The purchasing decision is then based on the cost of the cars and what the user can afford to pay. So far as prestige and super p restige cars are concerned, they charge a premium price and this has to be supported by their image. The positioning of a brand is

Wellshire NHS Trust Case Study Example | Topics and Well Written Essays - 1250 words

Wellshire NHS Trust - Case Study Example According to the paper, HR policies identified in the case study are centred towards nursing staff and their workplace environment. The fact finding report determined various problems that exists within two large hospitals operated by NHS Trust. There are four issues identified in the case study such as sickness absence, performance appraisal, employee relations, and learning and development. In recent years there has been increase in percentage of sickness absence. The major reason behind such problem can be lack of employee motivation. Staff members are not motivated enough to accomplish tasks or be regular in workplace practices. Stress related conditions have been so prominent in the organization that it initiated short term absence. In such scenario line managers should communicate effectively with team members. However data collected by line managers were not utilized further in order to resolve issues. It can be stated that initiatives were not undertaken by line managers and this created more problems in terms of increased degree of sickness absence. Inappropriate performance appraisal system can be denoted as another issue identified in the organization. Performance appraisal programs were undertaken by managers to address certain competencies such as communication, service improvement, people development, quality, health and safety, diversity and equality. Appraisal meetings were often not held in scheduled time period. There was no record maintained regarding employee performance and this issue gained more prominence in context of workplace shifts. The main reason behind this problem was lack of technology based applications. Hence it became difficult to track employee performance and implement productive strategies.  

Idea Of Chivalry And Double Jeopardy Criminology Essay

Idea Of Chivalry And Double Jeopardy Criminology Essay The purpose of the Criminal Justice System is to deliver justice to all, by protecting innocent members of the society, to punish and convict criminals and to provide help to them in an attempt to stop them offending; at least that is what the society expects of the Criminal Justice System. It is supposed to deliver justice in a fair manner regardless of gender. However much is written that suggests otherwise. Chivalry, believed by Pollak (1960) is a theory which claims that women are treated in a less harsh way by the courts and prisons because of their nature as women, which then distorts criminal statistics. However, Gregory Leonard (1982/83) disregard the chivalry factor as the cause of a gender gap in crime and Heidensohn (1985 cited in Jewkes and Letherby 2002 p.180) illustrates the theory of chivalry in a case reported in the Daily Mirror in January 1978 where a mother flogged her eight-year old son with a belt, gave him cold baths and forced him to stand naked for hours at night. The mother was jailed but later allowed to go freely because the courts said she needed to look after her other child. This case is a great illustration of how women are more favoured by the courts than men. This view can be seen as ideological and unsociological as it is based on female biology. Carmen (1983 cited in Jewkes and Letherby 2002 p.183) quotes sherrifs if she is a good mother we dont want to take her away. If shes not it doesnt really matter. This shows that the sentencing of a woman is based on her nurturing nature being of good standard or otherwise. A Home office study research 170, titled Understanding the sentencing of women was a study which made an effort to address the lack of extensive research into the way women are sentenced. The main aim of the study was to establish how the Magistrates go about taking account of the substantive differences in mens and womens lives and their perceptions of justice. The study was in two parts, in part 1 a test carried out suggested that women were less likely than comparable males to receive a prison sentence but they were more likely to be discharged or sentenced to a community penalty. However it was suggested that instead of the findings being interpreted as a general policy of leniency towards women, it should rather be seen that the sentencers may be reluctant to fine a woman possibly because they may be penalising her children, rather than just herself. This may have been all well and good if it were the days when majority of women still upheld their stereotypical domestic role as mothers and keepers of the home. It is part of family ideology that a womans place is in the home, while a mans task is to out to work to earn the money to support his wife and children (Allan, G 1999, p.191). However, we now live in a society where women are now bread winners, house hold duties are also taken on by men, women divorce their husbands for one reason or the other and consequently leaving the children behind for the father to take care of them. The Criminal Justice System might not take into account when sentencing men, that some of them are actually both mother and father to the children and carry out the role of the mother. In part 2 of the study nearly 200 Magistrates were interviewed; the Magistrates said they found it difficult to compare their sentencing between men and women because they dealt with female offenders less frequently. Nonetheless, they distinguished between troubled and troublesome and tended to locate most women in the troubled category. It was par tly because women tended to be first offenders, facing less serious charges than men and because they behaved more respectfully in court. The Magistrates went on to say that because they regarding women offenders as troubled, they responded to their offending with measures (a discharge or probation) designed to assist them to lead law abiding lives rather than punishing them. In an article by Jason Bennetto in The Independent, it is said that more women are committing violent crimes, particularly street robbery, burglary and fighting, and that part of the problem believed to be causing this is the result of neglect, abuse and drug or alcohol addiction. According to a report, Crimes of Desperation 2008, a significant amount of crime committed by females is rooted in poverty. As much as poverty may be the driving force for some, others may simply be using the money they have to fund their drug and alcohol use and subsequently turning to crime to further fund their tendencies. A Survey of over 1,000 mothers in prison, appears to provide some support for this report, 54% said they had no money, 38% needed to support their children, 35% were on drugs or alcoholics, 33% had family problems and 33%had no job. Caddle and Crisp (1997 cited in Newburn, T 2007 p.809) It was argued firstly by Freda Adler and later Rita Simon that female crime rates had been increasing rapidly in the late 80s and early 1970s and that they were changing their offending patterns to more masculine styles; it was due to the growth of the modern womens movement. (Maguire, M. Morgan, R. Reiner, R. 2012) In an empirical research looking at whether men and women offend for similar reasons, it was in relation to property crime that women featured most heavily in, which led to some commentators arguing that many women became involved in criminal activity for mostly to provide for children or family in circumstances where there are limited legitimate opportunities. (Newburn, T. 2007) The point is that female delinquents are not perceived to be merely adopting behaviour more usually associated with males, they are portrayed as being chromosomally or genetically abnormal. This means that the treatment of such o ¬Ã¢â€š ¬enders becomes justi ¬Ã‚ able, the aims, intentionality and rationality of the deviant act are overlooked and the social and cultural conditions under which the act took place can be relegated to the vague status of environ- mental factors whose only role is to occasionally trigger the inherent path- ology of the deviant. Crime and delinquency can thereby be treated as an individual, not social, phenomenon Smart (n.d) An alternative view to that of chivalry is double jeopardy. Heidensohn (1985) suggesting that female offenders are subjected to double jeopardy, meaning that when they are on trial, they are not only on trial for the crime they committed but also also for their femininity. Also, if any, female offenders are penalized for their sexual misconduct, while the male counterparts are not. Therefore the courts operate a double standard for female offenders. Womens low share of recorded criminality has significant consequences for those women who do offend: they are seen to have transgressed not only social norms but gender norms as well. As a result they may, especially when informal sanctions are being taken into account, feel that they are doubly punished. (Maguire, M. Morgan, R. Reiner, R. 2012) In murder cases, women get tougher sentences than men do, because in most cases the murder is premeditated. The case of R v Ahluwalia (1992) is about a woman who was being sexually abused, bullied and violently abused by her husband. After 10 years of abuse, she decided shed had enough and she poured petrol over her husbands body and set fire to him, six days later he died. She was convicted of murder because according S.3 of the Homicide act 1957 there must be a sudden and temporary loss of self-control which she did not possess at the time she killed her husband. It was seen as pre meditated because the abuse took place over 10 years. The defendant was then sentenced to life imprisonment, but was later released. Another case is the one of Zoorah Shah who was given a life sentence for killing her boyfriend by putting arsenic in his food. The courts did not take into account the fact that she was beaten regularly and exploited by her boyfriend to be prostitute. These cases are a majo r contrast to the case of David Hampson: a man smashed the head of his wife with a hammer and killed her. His reason for the murder was that his wife had nagged him for years. The judge accepted his reason as a reasonable excuse to be provoked to kill someone. He was convicted of manslaughter and sentenced to six years. Looking at these cases it shows the practicality of women being subjected to double jeopardy. It seems that these women are not only being punished for their crime but also because of their biological nature. Also, it seems to show that the courts believe that it is more acceptable for a man to lose his temper as opposed to a woman, because a womans nature is meant to be submissive, calm and rational. Some would say that women should not be aggressive as it is not in their nature. Womens nature should not be a deciding factor when sentencing, if particular sentence is rightly appropriate and deserved then it should be served. If the leniency on women offenders keeps being applied, it only means they wont learn their lesson and will not be deterred in the future to committing crime again. According to a report published in 2010 in the BBC news, statistics showed that re-offending rates by women went up by four times that for men by 16.4%, compared with 4.2%.

Democracy Essay example -- essays research papers

Democracy may be a word familiar to most, but still I would like to mention the fact that demos means pertaining to people and kratios means to rule. Thus this word original coined by the Greeks means rule of people as a whole and not by an individual or a privileged soul. It is a concept still misunderstood and misused in some parts of the world where totalitarian regimes and dictatorships have witnessed popular support by usurping democratic labels like in Iraq and Pakistan. By the dictionary definition, democracy is government by the people in which the supreme power is vested in the people and exercised directly by them or by their elected agents under a free electoral system. In a famous phrase of Abraham Lincoln, democracy is a government of the people, by the people, and for the people.Freedom and democracy are often used in place of each other, but the two are not the same. True, democracy is a set of ideas and principles about freedom, but it also consists of a set of pract ices and procedures that have been founded through a long history. In short, democracy is the institutionalization of freedom. For this reason, any society must possess time-tested fundamentals of constitutional government, human rights, and equality before the law to be properly called democratic. Democracies can be typified into two fundamental categories, direct and representative. In a direct democracy, all individuals, without the elected or appointed officials, can participate in making public decisions. This system however seems to be impractical possible only with relatively small numbers of people, say for example in a community organization, village of a developing country, tribal council, or the local unit of a labor union, where members can meet in a single room to discuss issues and arrive at decisions by consensus or majority vote. In rural India the head of such committees are called pancha and the place where issues for a small population of the concerned area are discussed is called panchayat.These meetings are held mostly under a village tree with the maximum number of people who can physically gather in one place and practice direct democracy.Modern society, with its enormous size, complexities and ramifications offers few avenues for direct democracy. Today, the most common form of democracy, whether for a town of 50,000 or nations of 50 million, is represe... ...titutional provisions to intervene in the administration of the States. The response of the Central Union Government to the growing economic and political crisis in India has been in terms of greater centralization strategies and interventions.Another equally important limitation of the Indian parliamentary democracy has been that below the state level it was not mandatory to have elected bodies at district, sub district or local level till 1994. In other words it was a system of parliamentary democracy at the central and state levels and bureaucratic governance at the lower levels. Grass root level democracy visualized in terms of selfreliant and selfgoverning villages was an important nationalist ideal. When the new constitution was framed, elected local bodies at the local levels were not made part of the mandatory structure of government, but enshrined in the Directive Principles of the constitution. By and large the Indian democracy is still in a phase of evolution and chang e. It seems that the concept of democracy is interpreted in a subjective manner and changes in nations from time to time according to the whims and fancies of the contemporary affluent and powerful people.